IL7R

Across TCGA cell cohorts, IL7R mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL7R-associated genes across cancer lineages are NXPE4, LRRC55, and GNGT1. Each is linked with IL7R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL7R-to-partner and partner-to-IL7R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXPE4 grouped by IL7R-low versus IL7R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL7R→partner) and Y-score (partner→IL7R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NXPE4 →	+1.102	+3.420	<.001	.003	3	2
BLOOD_Lymphoma	LRRC55 →	+0.077	+3.523	<.001	.009	3	2
BLOOD_Leukemia	GNGT1 →	+0.076	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TACR3 →	+0.038	+5.060	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

NXPE4 by IL7R expression — LARGE_INTESTINE

Explore this box plot interactively →