IL7R

Across TCGA pan-cancer cohorts, IL7R RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IL7R’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL7R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL7R is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where IL7R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL7R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.580	<.001	12	view →
LUSC	All	III,IV	−2.831	<.001	9	view →
LUAD	Female	III,IV	−2.077	<.001	9	view →
KIRC	Male	All	+1.641	<.001	8	view →
THCA	Female	All	−1.311	<.001	6	view →
KICH	All	II,III,IV	−1.098	.008	4	view →
STAD	All	All	+0.908	.007	4	view →
LIHC	Male	All	−0.993	<.001	2	view →
COAD	Female	All	−0.532	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IL7R–HNSC

Open the HNSC breakdown →