G protein subunit gamma transducin 1Genealiases: GNG1 · HG3G1
Q-omics provides the consensus-scored GNGT1 profile across patient tissues and cancer cell-line models. GNGT1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, GNGT1 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, GNGT1 RNA expression shows 13,943 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight COAD, HNSC, and THYM as cancer lineages where GNGT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GNGT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GNGT1 survival associations across molecular data types. GNGT1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GNGT1 RNA expression–survival associations across cancer types. High GNGT1 expression shows unfavorable associations in COAD, STAD, ACC, THCA and LIHC, but favorable associations in UCS. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for GNGT1 RNA expression.
This table summarizes GNGT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for GNGT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GNGT1 shows higher tumor expression in HNSC, KIRC, COAD, LUSC, LUAD and BLCA. The HNSC box plot shows higher GNGT1 RNA expression in tumor versus normal tissue (log2 FC = +2.269, t-test p < 0.001).
This table shows molecular features associated with GNGT1 in patient tissues and cancer cell lines. In patient samples, GNGT1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, GNGT1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS.
