GNGT1

Across TCGA cell cohorts, GNGT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,691 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GNGT1-associated GO terms across cancer lineages are Negative regulation of protein catabolic process, Amylin receptor 3 signaling pathway, and Ribosome-associated ubiquitin-dependent protein catabolic process. Each is linked with GNGT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both GNGT1-to-partner and partner-to-GNGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein catabolic process grouped by GNGT1-low versus GNGT1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNGT1→partner) and Y-score (partner→GNGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of protein catabolic process →	+0.066	+0.584	<.001	<.001	3	7
BLOOD_Myeloma	Amylin receptor 3 signaling pathway →	+0.200	+0.440	.002	.002	3	7
STOMACH	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.114	+0.814	.002	.001	3	6
LUNG_NSCLC_LUAD	Cytoplasmic translation →	+0.036	+0.389	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Protein folding →	+0.054	+0.641	<.001	<.001	3	5
LARGE_INTESTINE	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.078	+0.370	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,691 associations by consensus.

Negative regulation of protein catabolic process by GNGT1 expression — STOMACH

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