GNGT1

Across TCGA patient cohorts, GNGT1 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GNGT1-associated genes across cancer lineages are SNX3P1X, FAR1P1, and MIR6853. Each is linked with GNGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNGT1-to-partner and partner-to-GNGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX3P1X grouped by GNGT1-low versus GNGT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNGT1→partner) and Y-score (partner→GNGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNX3P1X →	+0.158	+5.469	<.001	.002	3	2
UCEC	FAR1P1 →	+0.113	+3.756	.008	.001	3	2
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
BRCA	SPATA31E3P →	+0.012	+5.721	<.001	.003	3	1
BRCA	LINC02366 →	+0.060	+5.506	.005	.005	3	1
BRCA	MIR548AD →	+0.225	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

SNX3P1X by GNGT1 expression — SKCM

Explore this box plot interactively →