Q-omics provides the consensus-scored IL27 profile across patient tissues and cancer cell-line models. IL27 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, IL27 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, IL27 RNA expression shows 13,729 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight SKCM, KIRC, and GBM as cancer lineages where IL27 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IL27 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IL27 survival associations across molecular data types. IL27 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IL27 RNA expression–survival associations across cancer types. High IL27 expression shows unfavorable associations in UVM, KIRC and THYM, but favorable associations in SKCM, LIHC and HNSC. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for IL27 RNA expression.
This table summarizes IL27 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for IL27. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IL27 shows lower tumor expression in LIHC, LUSC and LUAD and higher tumor expression in KIRC, HNSC and STAD. The KIRC box plot shows higher IL27 RNA expression in tumor versus normal tissue (log2 FC = +0.486, t-test p < 0.001).
This table shows molecular features associated with IL27 in patient tissues and cancer cell lines. In patient samples, IL27 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, IL27 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in CNS and BREAST.
