Across TCGA cell cohorts, IL27 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL27-associated genes across cancer lineages are HHLA1, TTLL8, and COX6A2. Each is linked with IL27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL27-to-partner and partner-to-IL27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL27→partner) and Y-score (partner→IL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
LARGE_INTESTINE	TTLL8 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	COX6A2 →	+0.102	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR10C1 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MEI4 →	+0.011	+4.684	<.001	.002	3	1
LARGE_INTESTINE	PPIAL4E →	+0.038	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

IL27 survival (RNA) · tumor vs normal (RNA) · all IL27 data types