Across TCGA pan-cancer cohorts, IL27 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IL27 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher IL27 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IL27 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, SARC, and GBM are the cancer types where IL27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.117	0.684	<.001	24	view →
SARC	DFS	Median	All	0.096	0.632	.003	12	view →
GBM	OS	Median	All	0.030	0.416	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.631	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IL27 tumor-vs-normal RNA expression · all IL27 data types