Across TCGA patient cohorts, IL27 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL27-associated genes across cancer lineages are C-Raf, Ku80, and MEK1. Each is linked with IL27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL27-to-partner and partner-to-IL27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL27→partner) and Y-score (partner→IL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.247	+3.169	<.001	.019	3	2
UCEC	Ku80 →	+0.379	+3.009	.001	.019	3	1
UCEC	MEK1 →	+0.455	+3.169	.013	.019	3	1
UCEC	PCNA →	+0.282	+2.321	.009	.035	3	1
UCEC	Tuberin →	+0.363	+2.321	.007	.035	3	1
UCEC	VHL →	-1.149	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

IL27 survival (RNA) · tumor vs normal (RNA) · all IL27 data types