IL17RE

Across TCGA patient cohorts, IL17RE mutation is significantly associated with the RNA expression of many other genes, with 1,820 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL17RE-associated genes across cancer lineages are IGLVIV-53, COPS8P1, and RNU1-154P. Each is linked with IL17RE in more than 2 cancer types. Because this analysis shows association rather than direction, both IL17RE-to-partner and partner-to-IL17RE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLVIV-53 grouped by IL17RE-low versus IL17RE-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RE→partner) and Y-score (partner→IL17RE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGLVIV-53 →	+0.125	+7.586	<.001	<.001	3	3
BLCA	COPS8P1 →	+0.119	+3.719	<.001	.008	3	3
BRCA	RNU1-154P →	+0.249	+5.347	<.001	.006	3	2
UCEC	MTA2 →	+0.437	+2.627	.001	.005	3	2
UCEC	CPSF7 →	+0.463	+3.823	<.001	<.001	3	2
UCEC	MRPL49 →	+0.557	+3.016	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,820 associations by consensus.

IGLVIV-53 by IL17RE expression — BRCA

Explore this box plot interactively →