IL17RE

Across TCGA pan-cancer cohorts, IL17RE RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IL17RE data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher IL17RE RNA is associated with better overall survival. In most high-consensus cancer types, elevated IL17RE expression acts as an unfavorable survival marker, although some lineages such as UVM and DLBC show a favorable association.

UVM, HNSC, and BRCA are the cancer types where IL17RE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.804	0.363	<.001	91	view →
HNSC	DFS	Tertile	IV	0.221	0.430	<.001	74	view →
BRCA	DFS	Quartile	III,IV	0.394	0.739	.007	51	view →
PAAD	OS	Tertile	All	0.539	0.742	.002	25	view →
UCEC	OS	Quartile	All	0.509	0.868	.003	24	view →
DLBC	DFS	Median	II,III,IV	0.971	0.541	.011	24	view →
THYM	OS	Median	All	1.000	0.631	<.001	22	view →
LUSC	DFS	Quartile	III,IV	0.184	0.501	.013	22	view →
MESO	OS	Median	All	0.509	0.277	.001	21	view →
KIRC	DFS	Median	All	0.725	0.526	.003	20	view →
LGG	DFS	Quartile	All	0.573	0.809	.001	17	view →
READ	DFS	Median	IV	0.936	0.179	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IL17RE–UVM (OS)

Open the UVM breakdown →