IGKV1-5

Across TCGA patient cohorts, IGKV1-5 protein abundance is significantly associated with the RNA expression of many other genes, with 9,518 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV1-5-associated genes across cancer lineages are FCRL5, IGHG1, and IGHV3-21. Each is linked with IGKV1-5 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGKV1-5-to-partner and partner-to-IGKV1-5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1-5 versus FCRL5 in UCEC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-5→partner) and Y-score (partner→IGKV1-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCRL5 →	+1.181	+0.882	<.001	<.001	3	6
OV	IGHG1 →	+4.376	+1.093	<.001	<.001	3	6
OV	IGHV3-21 →	+3.426	+1.115	<.001	<.001	3	6
OV	IGHV4-34 →	+2.297	+0.898	.003	.006	3	6
OV	IGHV3-30 →	+2.590	+1.070	.003	<.001	3	6
UCEC	IRF4 →	+1.197	+0.805	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,518 associations by consensus.

IGKV1-5 vs FCRL5 — UCEC

Explore this scatter interactively →