IGKV1-5

Across TCGA pan-cancer cohorts, IGKV1-5 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV1-5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1-5 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-5 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where IGKV1-5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−4.030	<.001	9	view →
LUAD	Female	All	+2.139	<.001	7	view →
LIHC	Male	All	−3.052	<.001	5	view →
KIRC	Male	All	+2.005	<.001	4	view →
BRCA	Female	II,III,IV	−0.945	.007	4	view →
KICH	All	II,III,IV	−2.074	.016	3	view →
READ	All	All	−3.366	.003	2	view →
HNSC	Female	III,IV	+2.677	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV1-5–COAD

Open the COAD breakdown →