IGKV1-5

Across TCGA pan-cancer cohorts, IGKV1-5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGKV1-5 data layer compared with 7 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1-5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.754	0.636	<.001	123	view →
SKCM	OS	Median	All	0.404	0.278	<.001	99	view →
BRCA	DFS	Tertile	All	0.646	0.484	<.001	73	view →
UVM	DFS	Tertile	All	0.489	0.894	.001	49	view →
SARC	OS	Median	All	0.894	0.778	.001	35	view →
LUAD	OS	Quartile	II,III,IV	0.660	0.287	.001	28	view →
UCEC	OS	Quartile	III,IV	0.698	0.294	.011	28	view →
LIHC	DFS	Median	III,IV	0.596	0.204	<.001	23	view →
COAD	DFS	Median	All	0.563	0.467	.019	17	view →
UCS	OS	Tertile	II,III,IV	0.678	0.321	.011	16	view →
CHOL	DFS	Median	All	0.628	0.210	.003	15	view →
KIRP	DFS	Quartile	All	0.508	0.913	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGKV1-5–HNSC (DFS)

Open the HNSC breakdown →