IGKV1-17

Across TCGA patient cohorts, IGKV1-17 protein abundance is significantly associated with the RNA expression of many other genes, with 3,623 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV1-17-associated genes across cancer lineages are TM4SF1-AS1, RNA5SP61, and ABHD3. Each is linked with IGKV1-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-17-to-partner and partner-to-IGKV1-17 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1-17 versus TM4SF1-AS1 in LSCC, with a Pearson correlation of -0.25.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-17→partner) and Y-score (partner→IGKV1-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TM4SF1-AS1 →	-0.737	-0.286	.001	.005	3	2
HNSC	RNA5SP61 →	-0.842	-0.614	.001	.008	3	2
UCEC	ABHD3 →	-0.880	-1.083	.001	.005	3	2
UCEC	ALKAL2 →	-1.790	-0.784	.008	.002	3	2
BRCA	RBBP7 →	-0.670	-0.636	<.001	<.001	3	2
LSCC	TIMELESS →	-0.535	-0.269	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,623 associations by consensus.

IGKV1-17 vs TM4SF1-AS1 — LSCC

Explore this scatter interactively →