IGKV1-17

Across TCGA pan-cancer cohorts, IGKV1-17 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGKV1-17’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1-17 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-17 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGKV1-17 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-17 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−4.581	<.001	10	view →
LUAD	Female	All	+2.088	<.001	7	view →
KIRC	Male	All	+1.809	<.001	5	view →
BRCA	Female	II,III,IV	−1.046	.001	4	view →
READ	All	All	−3.718	<.001	2	view →
CHOL	All	II,III,IV	−3.045	.024	2	view →
LIHC	Male	All	−2.312	<.001	2	view →
STAD	All	IV	−4.290	.038	1	view →
KICH	All	II,III,IV	−1.343	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGKV1-17–COAD

Open the COAD breakdown →