IGKV1-17

Across TCGA pan-cancer cohorts, IGKV1-17 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV1-17 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-17 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-17 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and COAD are the cancer types where IGKV1-17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.393	0.265	<.001	144	view →
SKCM	OS	Median	All	0.406	0.272	<.001	106	view →
COAD	DFS	Tertile	II,III,IV	0.835	0.615	.008	36	view →
GBM	OS	Quartile	All	0.329	0.511	.001	30	view →
STAD	DFS	Median	IV	0.670	0.171	.006	24	view →
KIRP	DFS	Quartile	All	0.529	0.928	.004	24	view →
UCEC	DFS	Tertile	III,IV	0.832	0.693	.017	24	view →
LIHC	DFS	Median	III,IV	0.590	0.210	<.001	23	view →
BRCA	OS	Quartile	All	0.976	0.939	.006	21	view →
TGCT	DFS	Median	All	0.927	0.736	.001	18	view →
KIRC	DFS	Tertile	All	0.471	0.694	.011	16	view →
SARC	OS	Median	All	0.811	0.673	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV1-17–HNSC (DFS)

Open the HNSC breakdown →