IGHV3-65

Across TCGA patient cohorts, IGHV3-65 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-65-associated genes across cancer lineages are SPAM1, LATS2-AS1, and STRIT1. Each is linked with IGHV3-65 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-65-to-partner and partner-to-IGHV3-65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPAM1 grouped by IGHV3-65-low versus IGHV3-65-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-65→partner) and Y-score (partner→IGHV3-65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPAM1 →	+0.040	+4.563	<.001	.004	3	1
SKCM	LATS2-AS1 →	+0.192	+4.296	<.001	.008	3	1
SKCM	STRIT1 →	+0.251	+4.296	<.001	.008	3	1
SKCM	RN7SL492P →	+0.325	+5.947	<.001	<.001	3	1
SKCM	SPATA31D5P →	+0.024	+4.381	<.001	.006	3	1
SKCM	GAPDHP50 →	+0.066	+5.118	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

SPAM1 by IGHV3-65 expression — SKCM

Explore this box plot interactively →