IGHV3-65

Across TCGA pan-cancer cohorts, IGHV3-65 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGHV3-65 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-65 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-65 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, ACC, and SKCM are the cancer types where IGHV3-65 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.754	0.640	<.001	144	view →
ACC	OS	Tertile	All	0.477	0.892	<.001	135	view →
SKCM	OS	Median	All	0.461	0.284	<.001	66	view →
BRCA	DFS	Median	All	0.965	0.933	.003	65	view →
UVM	OS	Tertile	II,III,IV	0.189	0.729	.001	45	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	40	view →
READ	OS	Median	II,III,IV	0.952	0.415	.007	35	view →
UCEC	OS	Tertile	III,IV	0.756	0.523	.036	18	view →
KIRP	DFS	Tertile	All	0.343	0.660	.013	16	view →
BLCA	DFS	Quartile	III,IV	0.654	0.515	.019	11	view →
CESC	DFS	Median	All	0.790	0.688	.031	10	view →
STAD	OS	Tertile	IV	0.918	0.300	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGHV3-65–HNSC (DFS)

Open the HNSC breakdown →