IGHV3-65

Across TCGA pan-cancer cohorts, IGHV3-65 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV3-65’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-65 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-65 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV3-65 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-65 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.124	<.001	10	view →
LUAD	Female	All	+0.825	<.001	7	view →
KIRC	Male	All	+0.278	<.001	6	view →
BLCA	Male	All	+0.311	.027	2	view →
BRCA	Female	All	−0.145	.026	2	view →
HNSC	All	III,IV	+0.426	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHV3-65–COAD

Open the COAD breakdown →