IGHV1-12

Across TCGA patient cohorts, IGHV1-12 RNA expression is significantly associated with the RNA expression of many other genes, with 9,226 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible IGHV1-12-associated genes across cancer lineages are IGHV3-30, IGKV3D-20, and IGLV4-69. Each is linked with IGHV1-12 in more than 32 cancer types. Because this analysis shows association rather than direction, both IGHV1-12-to-partner and partner-to-IGHV1-12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV1-12 versus IGHV3-30 in THCA, with a Pearson correlation of 0.84.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-12→partner) and Y-score (partner→IGHV1-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	IGHV3-30 →	+4.864	+2.195	<.001	<.001	3	33
THCA	IGKV3D-20 →	+3.615	+2.211	<.001	<.001	3	33
CHOL	IGLV4-69 →	+4.291	+2.125	<.001	<.001	3	33
CHOL	IGLV3-25 →	+4.907	+2.066	<.001	.001	3	33
THCA	IGLV3-19 →	+5.059	+2.178	<.001	<.001	3	33
HNSC	IGLV2-18 →	+2.912	+2.620	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,226 associations by consensus.

IGHV1-12 vs IGHV3-30 — THCA

Explore this scatter interactively →