IGHV1-12

Across TCGA pan-cancer cohorts, IGHV1-12 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV1-12 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-12 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1-12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGHV1-12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.784	0.635	<.001	129	view →
BRCA	DFS	Tertile	All	0.565	0.460	<.001	105	view →
SKCM	DFS	Median	All	0.833	0.675	<.001	80	view →
ACC	DFS	Tertile	III,IV	0.010	0.458	<.001	63	view →
GBM	OS	Tertile	All	0.199	0.437	<.001	45	view →
UCEC	DFS	Median	III,IV	0.705	0.439	.012	32	view →
UCS	DFS	Tertile	All	0.672	0.353	.024	24	view →
PAAD	OS	Tertile	II,III,IV	0.692	0.412	.001	22	view →
MESO	OS	Median	All	0.755	0.271	<.001	18	view →
STAD	OS	Tertile	All	0.492	0.704	.017	13	view →
UVM	OS	Tertile	All	0.400	0.706	.037	12	view →
TGCT	DFS	Tertile	All	0.969	0.781	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGHV1-12–HNSC (DFS)

Open the HNSC breakdown →