Q-omics provides the consensus-scored IGLV2-18 profile across patient tissues and cancer cell-line models. IGLV2-18 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, IGLV2-18 is differentially expressed in 7, with the highest sampling consensus in COAD. Additionally, IGLV2-18 protein abundance shows 15,773 significant protein co-abundance associations, with the highest sampling consensus in CCRCC. Together, these results highlight HNSC, COAD, and CCRCC as cancer lineages where IGLV2-18 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IGLV2-18 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IGLV2-18 survival associations across molecular data types. IGLV2-18 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (1) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IGLV2-18 RNA expression–survival associations across cancer types. High IGLV2-18 expression shows favorable associations in HNSC, SKCM, UCEC, LUAD, COAD and BRCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for IGLV2-18 RNA expression.
This table summarizes IGLV2-18 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7, while mass-spec protein shows differences in 6. The strongest signals are observed in COAD for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for IGLV2-18. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IGLV2-18 shows lower tumor expression in COAD, LIHC, BRCA and READ and higher tumor expression in LUAD and KIRC. The COAD box plot shows higher IGLV2-18 RNA expression in normal versus tumor tissue (log2 FC = −2.631, t-test p < 0.001).
This table shows molecular features associated with IGLV2-18 in patient tissues and cancer cell lines. In patient samples, IGLV2-18 shows the broadest associations at the RNA and protein expression levels, with CCRCC recurring as the lineage with the largest associated feature set.
