Across TCGA pan-cancer cohorts, IGLV2-18 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGLV2-18 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV2-18 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV2-18 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGLV2-18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.750	0.641	<.001	147	view →
SKCM	DFS	Median	All	0.676	0.556	<.001	87	view →
UCEC	DFS	Median	III,IV	0.871	0.714	.001	66	view →
LUAD	DFS	Quartile	III,IV	0.812	0.293	.001	59	view →
COAD	DFS	Tertile	All	0.784	0.634	.003	48	view →
BRCA	DFS	Median	All	0.963	0.934	.002	43	view →
ACC	DFS	Tertile	All	0.802	0.478	.003	30	view →
KIRP	OS	Median	All	0.605	0.901	.002	29	view →
STAD	OS	Median	IV	0.642	0.194	.003	21	view →
LIHC	DFS	Median	All	0.623	0.474	.006	17	view →
KIRC	DFS	Quartile	All	0.413	0.697	.002	16	view →
READ	DFS	Median	IV	0.792	0.329	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

Exploration

Same gene, other analysis: IGLV2-18 tumor-vs-normal RNA expression · all IGLV2-18 data types