IFI44

Across TCGA cell cohorts, IFI44 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFI44-associated genes across cancer lineages are SPATA48, C10orf71, and ACER1. Each is linked with IFI44 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI44-to-partner and partner-to-IFI44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by IFI44-low versus IFI44-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI44→partner) and Y-score (partner→IFI44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPATA48 →	+0.019	+4.977	<.001	.007	3	1
SKIN	C10orf71 →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ACER1 →	+0.098	+4.145	<.001	.001	3	1
LARGE_INTESTINE	OR2C1 →	+0.098	+3.725	.003	.008	3	1
CNS	CST9 →	+0.042	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SPATA48 by IFI44 expression — SKIN

Explore this box plot interactively →