IFI44

Across TCGA pan-cancer cohorts, IFI44 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated IFI44 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IFI44 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFI44 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CHOL show a favorable association.

KIRC, ACC, and SKCM are the cancer types where IFI44 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.494	0.721	<.001	136	view →
ACC	OS	Tertile	All	0.755	0.974	<.001	74	view →
SKCM	OS	Tertile	All	0.401	0.260	<.001	65	view →
LGG	DFS	Median	All	0.629	0.838	<.001	54	view →
UCEC	DFS	Tertile	All	0.559	0.821	.001	52	view →
UVM	DFS	Quartile	III,IV	0.215	0.715	.012	46	view →
THYM	DFS	Tertile	All	0.832	0.978	.002	42	view →
CHOL	DFS	Tertile	II,III,IV	0.816	0.150	.001	26	view →
HNSC	DFS	Tertile	IV	0.512	0.762	.014	19	view →
READ	DFS	Median	II,III,IV	0.654	0.372	.007	14	view →
PAAD	DFS	Quartile	All	0.250	0.575	.019	12	view →
SARC	DFS	Quartile	All	0.247	0.539	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

IFI44–KIRC (DFS)

Open the KIRC breakdown →