IFI44

Across TCGA pan-cancer cohorts, IFI44 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IFI44’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IFI44 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFI44 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where IFI44 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFI44 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.315	<.001	11	view →
KICH	Male	II,III,IV	−2.187	<.001	11	view →
KIRC	Male	IV	+1.290	<.001	11	view →
BLCA	All	All	+1.279	.002	8	view →
COAD	Male	All	+1.162	<.001	6	view →
LUSC	Male	III,IV	−2.052	<.001	5	view →
BRCA	All	All	+0.543	<.001	4	view →
CHOL	All	All	+1.332	.002	3	view →
STAD	All	All	+0.997	.002	3	view →
ESCA	All	All	+1.476	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IFI44–HNSC

Open the HNSC breakdown →