chromosome 10 open reading frame 71Genealiases: CEFIP · CMD1QQ
Q-omics provides the consensus-scored C10orf71 profile across patient tissues and cancer cell-line models. C10orf71 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, C10orf71 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, C10orf71 RNA expression shows 10,728 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight THCA, KIRC, and HNSC as cancer lineages where C10orf71 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C10orf71 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C10orf71 survival associations across molecular data types. C10orf71 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (7) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C10orf71 RNA expression–survival associations across cancer types. High C10orf71 expression shows unfavorable associations in THCA, LUSC, MESO, HNSC and THYM, but favorable associations in ESCA. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for C10orf71 RNA expression.
This table summarizes C10orf71 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for C10orf71. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C10orf71 shows lower tumor expression in KIRC, KIRP, HNSC and BLCA and higher tumor expression in LUAD and ESCA. The KIRC box plot shows higher C10orf71 RNA expression in normal versus tumor tissue (log2 FC = −0.415, t-test p < 0.001).
This table shows molecular features associated with C10orf71 in patient tissues and cancer cell lines. In patient samples, C10orf71 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, C10orf71 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and LARGE_INTESTINE.
