HOXB6

Across TCGA patient cohorts, HOXB6 mutation is significantly associated with the RNA expression of many other genes, with 531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB6-associated genes across cancer lineages are RNU6ATAC42P, RN7SL248P, and RNA5SP198. Each is linked with HOXB6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXB6-to-partner and partner-to-HOXB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC42P grouped by HOXB6-low versus HOXB6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB6→partner) and Y-score (partner→HOXB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6ATAC42P →	+0.402	+4.594	<.001	.008	3	3
CESC	RN7SL248P →	+0.127	+6.000	<.001	<.001	3	2
CESC	RNA5SP198 →	+0.218	+4.559	<.001	.006	3	2
UCEC	RNU6ATAC30P →	+0.287	+2.002	.003	.006	3	2
UCEC	RN7SKP264 →	+0.183	+2.477	.001	.002	3	2
UCEC	PINCR →	+0.250	+2.979	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 531 associations by consensus.

RNU6ATAC42P by HOXB6 expression — SKCM

Explore this box plot interactively →