Q-omics provides the consensus-scored PINCR profile across patient tissues and cancer cell-line models. PINCR expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, PINCR is differentially expressed in 6, with the highest sampling consensus in THCA. Additionally, PINCR RNA expression shows 8,451 significant mutation-linked associations, with the highest sampling consensus in UCEC. Together, these results highlight UVM, THCA, and UCEC as cancer lineages where PINCR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PINCR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PINCR survival associations across molecular data types. PINCR RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PINCR RNA expression–survival associations across cancer types. High PINCR expression shows unfavorable associations in UVM, MESO, KIRP, LUSC, LIHC and LGG. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for PINCR RNA expression.
This table summarizes PINCR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for PINCR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PINCR shows higher tumor expression in THCA, BRCA, UCEC, CHOL, KIRC and LUAD. The THCA box plot shows higher PINCR RNA expression in tumor versus normal tissue (log2 FC = +0.009, t-test p = .003).
This table shows molecular features associated with PINCR in patient tissues and cancer cell lines. In patient samples, PINCR shows the broadest associations at the RNA and protein expression levels, with UCEC recurring as the lineage with the largest associated feature set.
