Across TCGA pan-cancer cohorts, PINCR RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PINCR’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where PINCR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PINCR is over-expressed in tumor.
THCA, BRCA, and UCEC are the cancer types where PINCR tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PINCR RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.