HOXB6

Across TCGA pan-cancer cohorts, HOXB6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HOXB6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXB6 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXB6 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where HOXB6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXB6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.579	<.001	12	view →
HNSC	Male	All	+1.067	<.001	9	view →
BLCA	Male	All	+1.390	<.001	8	view →
COAD	Male	II,III,IV	+1.174	.003	8	view →
KICH	Male	All	−1.809	<.001	7	view →
THCA	All	All	+0.295	<.001	7	view →
BRCA	Female	II,III,IV	+0.591	.001	6	view →
STAD	Male	All	+1.163	.009	4	view →
CHOL	Male	All	+3.043	.002	3	view →
KIRP	All	All	−1.269	<.001	3	view →
LIHC	Female	All	+0.333	.015	3	view →
PAAD	All	All	+2.190	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HOXB6–KIRC

Open the KIRC breakdown →