Across TCGA patient cohorts, HLA-J mutation is significantly associated with the RNA expression of many other genes, with 556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-J-associated genes across cancer lineages are PSAT1P4, KRTAP8-1, and MIR153-1. Each is linked with HLA-J in more than 2 cancer types. Because this analysis shows association rather than direction, both HLA-J-to-partner and partner-to-HLA-J results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-J→partner) and Y-score (partner→HLA-J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PSAT1P4 →	+0.141	+5.038	<.001	.009	3	3
BRCA	KRTAP8-1 →	+0.207	+4.800	<.001	.006	3	2
BRCA	MIR153-1 →	+0.600	+4.540	<.001	.009	3	2
SKCM	OR4F4 →	+0.028	+5.212	<.001	.002	3	2
SKCM	LINC02038 →	+0.070	+3.765	.004	.007	3	2
UCEC	SFPQP1 →	+0.073	+2.741	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

Exploration

HLA-J survival (RNA) · tumor vs normal (RNA) · all HLA-J data types