Across TCGA pan-cancer cohorts, HLA-J RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HLA-J’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-J RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-J is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.
KIRC, HNSC, and STAD are the cancer types where HLA-J tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-J RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.