GOT2

Across TCGA patient cohorts, GOT2 mutation is significantly associated with the RNA expression of many other genes, with 529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOT2-associated genes across cancer lineages are LDHBP3, P3R3URF, and TRAJ12. Each is linked with GOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOT2-to-partner and partner-to-GOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LDHBP3 grouped by GOT2-low versus GOT2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT2→partner) and Y-score (partner→GOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LDHBP3 →	+0.296	+4.623	<.001	.001	3	2
LUSC	P3R3URF →	+0.131	+4.993	<.001	.003	3	2
UCEC	TRAJ12 →	+0.524	+2.122	.001	.002	3	2
LUAD	RNU6-642P →	+0.260	+3.890	.008	.006	3	1
LUAD	MT1CP →	+0.305	+3.659	<.001	.009	3	1
LUAD	TRAJ57 →	+0.526	+3.821	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 529 associations by consensus.

LDHBP3 by GOT2 expression — LUSC

Explore this box plot interactively →