GOT2

Across TCGA pan-cancer cohorts, GOT2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GOT2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GOT2 RNA is repressed in tumor relative to normal tissue. In most cancer types GOT2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, LUAD, and THCA are the cancer types where GOT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GOT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.083	<.001	11	view →
LUAD	Male	II,III,IV	+0.875	<.001	9	view →
THCA	Male	III,IV	−0.751	<.001	9	view →
COAD	Female	II,III,IV	+0.623	<.001	9	view →
LUSC	Female	All	+1.159	<.001	8	view →
LIHC	Male	II,III,IV	−0.960	<.001	8	view →
BRCA	All	III,IV	+0.936	<.001	6	view →
KIRP	All	II,III,IV	+0.416	.009	4	view →
CHOL	All	All	−1.412	<.001	3	view →
STAD	All	IV	+0.823	.014	3	view →
READ	All	III,IV	+0.600	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GOT2–KIRC

Open the KIRC breakdown →