GLIDR

Across TCGA patient cohorts, GLIDR mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLIDR-associated genes across cancer lineages are RPIAP1, TBC1D3C, and BCRP6. Each is linked with GLIDR in more than 1 cancer types. Because this analysis shows association rather than direction, both GLIDR-to-partner and partner-to-GLIDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPIAP1 grouped by GLIDR-low versus GLIDR-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIDR→partner) and Y-score (partner→GLIDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPIAP1 →	+0.084	+4.116	.007	.004	3	2
BRCA	TBC1D3C →	+0.024	+3.844	.003	.007	3	1
BRCA	BCRP6 →	+0.228	+4.331	<.001	.003	3	1
BRCA	MFFP3 →	+0.038	+4.386	.002	.008	3	1
BRCA	HMGB3P11 →	+0.165	+6.441	<.001	<.001	3	1
BRCA	BOLA3P3 →	+0.372	+4.108	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

RPIAP1 by GLIDR expression — BRCA

Explore this box plot interactively →