high mobility group box 3 pseudogene 11Genealiases: []
Q-omics provides the consensus-scored HMGB3P11 profile across patient tissues and cancer cell-line models. HMGB3P11 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, HMGB3P11 is differentially expressed in 4, with the highest sampling consensus in KIRP. Additionally, HMGB3P11 RNA expression shows 7,629 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight MESO, KIRP, and GBM as cancer lineages where HMGB3P11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HMGB3P11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HMGB3P11 survival associations across molecular data types. HMGB3P11 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HMGB3P11 RNA expression–survival associations across cancer types. High HMGB3P11 expression shows unfavorable associations in MESO, UCEC, LUSC, LAML, THCA and LGG. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify MESO as the clearest survival context for HMGB3P11 RNA expression.
This table summarizes HMGB3P11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for HMGB3P11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HMGB3P11 shows lower tumor expression in KIRP and KICH and higher tumor expression in LUAD and STAD. The KIRP box plot shows higher HMGB3P11 RNA expression in normal versus tumor tissue (log2 FC = −0.066, t-test p = .013).
This table shows molecular features associated with HMGB3P11 in patient tissues and cancer cell lines. In patient samples, HMGB3P11 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
