Q-omics provides the consensus-scored GK-IT1 profile across patient tissues and cancer cell-line models. GK-IT1 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, GK-IT1 is differentially expressed in 7, with the highest sampling consensus in COAD. Additionally, GK-IT1 RNA expression shows 15,117 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, COAD, and GBM as cancer lineages where GK-IT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GK-IT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GK-IT1 survival associations across molecular data types. GK-IT1 RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GK-IT1 RNA expression–survival associations across cancer types. High GK-IT1 expression shows unfavorable associations in KIRC, COAD, ACC, LGG, ESCA and BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for GK-IT1 RNA expression.
This table summarizes GK-IT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for GK-IT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GK-IT1 shows lower tumor expression in LUSC and higher tumor expression in COAD, ESCA, STAD, BRCA and LUAD. The COAD box plot shows higher GK-IT1 RNA expression in tumor versus normal tissue (log2 FC = +0.269, t-test p = .004).
This table shows molecular features associated with GK-IT1 in patient tissues and cancer cell lines. In patient samples, GK-IT1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
