GK-IT1

Across TCGA pan-cancer cohorts, GK-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated GK-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GK-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GK-IT1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and CHOL show a favorable association.

KIRC, COAD, and LGG are the cancer types where GK-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.516	0.716	<.001	136	view →
COAD	DFS	Median	III,IV	0.579	0.745	.002	38	view →
LGG	OS	Tertile	All	0.811	0.921	<.001	31	view →
ACC	DFS	Quartile	All	0.229	0.677	<.001	31	view →
ESCA	OS	Median	All	0.391	0.612	<.001	25	view →
BRCA	OS	Quartile	IV	0.228	0.758	.017	21	view →
KICH	OS	Quartile	All	0.609	0.943	.029	19	view →
LIHC	DFS	Tertile	All	0.468	0.623	.003	17	view →
BLCA	DFS	Quartile	All	0.509	0.267	.007	12	view →
UVM	OS	Tertile	III,IV	0.220	0.872	.025	9	view →
CHOL	DFS	Tertile	III,IV	0.751	0.094	.024	9	view →
MESO	OS	Tertile	IV	0.339	0.690	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

GK-IT1–KIRC (DFS)

Open the KIRC breakdown →