GK-IT1

Across TCGA pan-cancer cohorts, GK-IT1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of GK-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GK-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GK-IT1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

COAD, ESCA, and STAD are the cancer types where GK-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GK-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.269	.004	5	view →
ESCA	All	II,III,IV	+1.740	.004	4	view →
STAD	All	All	+0.579	.002	4	view →
BRCA	Female	All	+0.130	.016	4	view →
LUAD	All	II,III,IV	+0.377	.031	1	view →
LUSC	All	All	−0.243	.029	1	view →
KIRP	All	All	+0.126	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

GK-IT1–COAD

Open the COAD breakdown →