fucosyltransferase 1 (H blood group)Genealiases: H · HH · HSC
Q-omics provides the consensus-scored FUT1 profile across patient tissues and cancer cell-line models. FUT1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, FUT1 is differentially expressed in 12, with the highest sampling consensus in COAD. Additionally, FUT1 RNA expression shows 17,290 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LUAD, COAD, and UVM as cancer lineages where FUT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FUT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FUT1 survival associations across molecular data types. FUT1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FUT1 RNA expression–survival associations across cancer types. High FUT1 expression shows unfavorable associations in KIRP, COAD and UVM, but favorable associations in LUAD, KIRC and SCLC. The LUAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for FUT1 RNA expression.
This table summarizes FUT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 1. The strongest signals are observed in HNSC for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for FUT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FUT1 shows lower tumor expression in KIRP and LUAD and higher tumor expression in COAD, HNSC, LIHC and THCA. The COAD box plot shows higher FUT1 RNA expression in tumor versus normal tissue (log2 FC = +2.342, t-test p < 0.001).
This table shows molecular features associated with FUT1 in patient tissues and cancer cell lines. In patient samples, FUT1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, FUT1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and LUNG_SCLC.
