family with sequence similarity 81 member BGenealiases: []
Q-omics provides the consensus-scored FAM81B profile across patient tissues and cancer cell-line models. FAM81B expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, FAM81B is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, FAM81B RNA expression shows 14,744 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KICH as cancer lineages where FAM81B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM81B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM81B survival associations across molecular data types. FAM81B RNA expression shows survival associations in the most cancer types (26), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM81B RNA expression–survival associations across cancer types. High FAM81B expression shows unfavorable associations in UVM, DLBC, LIHC and LGG, but favorable associations in BRCA and LUSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify UVM as the clearest survival context for FAM81B RNA expression.
This table summarizes FAM81B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for FAM81B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM81B shows lower tumor expression in KICH, THCA, LUSC, LUAD and KIRC and higher tumor expression in BRCA. The KICH box plot shows higher FAM81B RNA expression in normal versus tumor tissue (log2 FC = −1.997, t-test p < 0.001).
This table shows molecular features associated with FAM81B in patient tissues and cancer cell lines. In patient samples, FAM81B shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM81B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
