FAM81B

Across TCGA cell cohorts, FAM81B mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FAM81B-associated genes across cancer lineages are SPRR2G, KLK12, and IFNA14. Each is linked with FAM81B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM81B-to-partner and partner-to-FAM81B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR2G grouped by FAM81B-low versus FAM81B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM81B→partner) and Y-score (partner→FAM81B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPRR2G →	+0.707	+4.930	<.001	.008	3	2
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	1
LUNG_SCLC	OR13C4 →	+0.165	+5.029	<.001	.006	3	1
BLOOD_Leukemia	LCN9 →	+1.066	+4.539	<.001	.007	3	1
LARGE_INTESTINE	ENTHD1 →	+0.035	+4.139	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SPRR2G by FAM81B expression — SOFT_TISSUE

Explore this box plot interactively →