FAM81B

Across TCGA patient cohorts, FAM81B mutation is significantly associated with the RNA expression of many other genes, with 3,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM81B-associated genes across cancer lineages are RNU6-1183P, SLC25A4, and ATP5F1A. Each is linked with FAM81B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM81B-to-partner and partner-to-FAM81B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1183P grouped by FAM81B-low versus FAM81B-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM81B→partner) and Y-score (partner→FAM81B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNU6-1183P →	+0.677	+5.584	<.001	.003	3	2
UCEC	SLC25A4 →	+0.566	+2.470	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.434	+2.470	.002	<.001	3	2
UCEC	PCGF6 →	+0.487	+2.102	.001	.001	3	2
UCEC	CHRNA5 →	+0.579	+3.470	.001	.002	3	2
UCEC	ELP5 →	+0.361	+2.970	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,718 associations by consensus.

RNU6-1183P by FAM81B expression — GBM

Explore this box plot interactively →