FAM81B

Across TCGA patient cohorts, FAM81B mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM81B-associated genes across cancer lineages are C-Raf, c-Met_pY1235, and 14-3-3_beta. Each is linked with FAM81B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM81B-to-partner and partner-to-FAM81B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FAM81B-low versus FAM81B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM81B→partner) and Y-score (partner→FAM81B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.188	+1.925	<.001	.005	3	3
UCEC	c-Met_pY1235 →	+0.063	+1.594	.019	.021	3	2
UCEC	14-3-3_beta →	-0.081	-2.088	.024	.016	3	1
UCEC	EGFR_pY1068 →	-0.180	-1.700	.046	.042	3	1
UCEC	eIF4E →	+0.217	+2.807	.004	<.001	3	1
UCEC	eIF4G →	+0.245	+1.700	.028	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

C-Raf by FAM81B expression — UCEC

Explore this box plot interactively →