Across TCGA patient cohorts, FAM74A1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM74A1-associated genes across cancer lineages are RNA5SP305, RNU6-1260P, and RNU1-83P. Each is linked with FAM74A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM74A1-to-partner and partner-to-FAM74A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM74A1→partner) and Y-score (partner→FAM74A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP305 →	+0.546	+4.081	<.001	.002	3	1
UCEC	RNU6-1260P →	+0.295	+4.226	<.001	.008	3	1
UCEC	RNU1-83P →	+0.555	+3.889	<.001	.004	3	1
UCEC	RNA5SP205 →	+0.612	+4.852	<.001	<.001	3	1
UCEC	RNU6-541P →	+0.415	+3.638	.003	.006	3	1
UCEC	RNU6-1228P →	+0.343	+5.049	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

FAM74A1 survival (RNA) · tumor vs normal (RNA) · all FAM74A1 data types