family with sequence similarity 47 member CGenealiases: []
Q-omics provides the consensus-scored FAM47C profile across patient tissues and cancer cell-line models. FAM47C expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in THYM. Among the 18 cancer types available for tumor–normal comparison, FAM47C is differentially expressed in 7, with the highest sampling consensus in THCA. Additionally, FAM47C RNA expression shows 7,216 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight THYM, THCA, and TGCT as cancer lineages where FAM47C shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM47C — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM47C survival associations across molecular data types. FAM47C RNA expression shows survival associations in the most cancer types (16), followed by mutation status (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM47C RNA expression–survival associations across cancer types. High FAM47C expression shows unfavorable associations in THYM, COAD, KIRP, UCEC, PCPG and DLBC. The THYM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THYM as the clearest survival context for FAM47C RNA expression.
This table summarizes FAM47C tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for FAM47C. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM47C shows lower tumor expression in THCA, KICH, BRCA and KIRC and higher tumor expression in BLCA and UCEC. The THCA box plot shows higher FAM47C RNA expression in normal versus tumor tissue (log2 FC = −0.076, t-test p < 0.001).
This table shows molecular features associated with FAM47C in patient tissues and cancer cell lines. In patient samples, FAM47C shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM47C RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in BONE and LARGE_INTESTINE.
