Across TCGA patient cohorts, FAM47C mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM47C-associated genes across cancer lineages are STAT3_pY705, FOXO3a_pS318_S321, and Caspase-7-cleavedD198. Each is linked with FAM47C in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM47C-to-partner and partner-to-FAM47C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM47C→partner) and Y-score (partner→FAM47C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.277	-1.459	<.001	.009	3	4
UCEC	FOXO3a_pS318_S321 →	-0.076	-1.146	.024	.011	3	4
UCEC	Caspase-7-cleavedD198 →	+0.547	+1.260	<.001	.008	3	4
LUSC	p38-MAPK_pT180_Y182 →	-0.270	-2.321	.012	.004	3	3
UCEC	ACC1 →	+0.210	+1.598	.032	.019	3	3
COAD	NF2 →	+0.153	+1.749	.019	.049	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Exploration

FAM47C survival (RNA) · tumor vs normal (RNA) · all FAM47C data types