family with sequence similarity 21 member E, pseudogeneGenealiases: []
Q-omics provides the consensus-scored FAM21EP profile across patient tissues and cancer cell-line models. FAM21EP expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, FAM21EP is differentially expressed in 12, with the highest sampling consensus in LUAD. Additionally, FAM21EP RNA expression shows 12,373 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, LUAD, and UVM as cancer lineages where FAM21EP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM21EP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM21EP survival associations across molecular data types. FAM21EP RNA expression shows survival associations in the most cancer types (21), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM21EP RNA expression–survival associations across cancer types. High FAM21EP expression shows unfavorable associations in KIRC, LAML and UVM, but favorable associations in LGG, LUAD and ACC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for FAM21EP RNA expression.
This table summarizes FAM21EP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for FAM21EP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM21EP shows lower tumor expression in LUAD and KICH and higher tumor expression in BLCA, LIHC, KIRC and STAD. The LUAD box plot shows higher FAM21EP RNA expression in normal versus tumor tissue (log2 FC = −0.234, t-test p < 0.001).
This table shows molecular features associated with FAM21EP in patient tissues and cancer cell lines. In patient samples, FAM21EP shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
